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本文引用的文献

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Interactions of newly designed dicationic carbazole derivatives with double-stranded DNA: syntheses, binding studies and AFM imaging.新型二价咔唑衍生物与双链 DNA 的相互作用：合成、结合研究和 AFM 成像。
Org Biomol Chem. 2013 Sep 7;11(33):5512-20. doi: 10.1039/c3ob40799c.
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Substituent effect on the preferred DNA binding mode and affinity of a homologous series of naphthalene diimides.取代基效应对一系列萘二酰亚胺同系物首选 DNA 结合模式和亲和力的影响。
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Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay.使用拓扑异构酶I DNA解旋测定法对DNA结合剂进行结合模式和亲和力研究。
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Screening of threading bis-intercalators binding to duplex DNA by electrospray ionization tandem mass spectrometry.通过电喷雾电离串联质谱法筛选与双链DNA结合的穿线双插入剂
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Sequence-selective DNA recognition: natural products and nature's lessons.序列选择性DNA识别：天然产物与自然的启示
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8
NMR structural analysis of a modular threading tetraintercalator bound to DNA.与DNA结合的模块化穿线四插入剂的核磁共振结构分析。
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Recognition of duplex RNA by helix-threading peptides.螺旋穿线肽对双链RNA的识别。
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10
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity.一种用于确定DNA结合选择性和亲和力的荧光嵌入剂置换分析法。
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N-单取代和N,N'-二取代吲哚并[3,2-b]咔唑的合成及DNA结合谱

Synthesis and DNA binding profile of N-mono- and N,N'-disubstituted indolo[3,2-b]carbazoles.

作者信息

Panesar Harmanpreet Kaur, Solano Jennifer, Minehan Thomas G

机构信息

Department of Chemistry and Biochemistry, California State University, Northridge, 18111 Nordhoff Street, Northridge, CA 91330, USA.

出版信息

Org Biomol Chem. 2015 Mar 14;13(10):2879-83. doi: 10.1039/c4ob02566k.

DOI:10.1039/c4ob02566k
PMID:25633133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4339310/
Abstract

A series of N-monosubstituted and N,N'-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It has been found that indolo[3,2-b]carbazoles bearing basic N-alkyl substituents are intercalators that bind DNA with affinities in the micromolar and submicromolar range and a preference for associating with sequences of mixed composition and purine-pyrimidine steps.

摘要

已制备了一系列吲哚并[3,2 - b]咔唑发色团的N - 单取代和N,N'- 二取代衍生物，并通过紫外和荧光光谱法评估了它们与双链DNA的结合亲和力。已发现带有碱性N - 烷基取代基的吲哚并[3,2 - b]咔唑是嵌入剂，它们以微摩尔和亚微摩尔范围内的亲和力结合DNA，并且优先与混合组成和嘌呤 - 嘧啶步的序列缔合。