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一个用于预测1年死亡率的预后指数也能够预测老年内科患者的住院死亡率。

A prognostic index for 1-year mortality can also predict in-hospital mortality of elderly medical patients.

作者信息

Cei Marco, Mumoli Nicola, Vitale José, Dentali Francesco

机构信息

Department of Internal Medicine, Ospedale Civile di Livorno, Viale Alfieri, 36, 57124, Livorno, Italy.

出版信息

Intern Emerg Med. 2015 Aug;10(5):575-9. doi: 10.1007/s11739-015-1196-6. Epub 2015 Jan 30.

Abstract

Elderly patients admitted to the hospital are at increased risk for both in-hospital and post-discharge mortality. Risk assessment models (RAMs) for in-hospital mortality are based mainly on physiological variables and a few laboratory data, whereas RAMs for late mortality usually include other domains such as disability and comorbidities. We aim to evaluate if a previous validated model for 1-year mortality (the Walter Score) would also work well in predicting in-hospital mortality. We retrospectively revised the medical records of patients admitted on our ward, from April to December, 2013. Data regarding gender, activities of daily living (ADLs), comorbidities, and routine laboratory tests were used to calculate a Modified Walter Score (MoWS). The main outcome measure was all cause, in-hospital mortality. The analysis involved 1,004 patients. Of these, 888 were discharged alive, and 116 (11.5 %) died during the hospitalization. The mean MoWS was 4.9 (±3.6) in the whole sample. Stratification into risk classes parallels with in-hospital mortality (Chi square for trend p < 0.001). When dichotomized, MoWS has a sensitivity of 97.4 % (95 % CI 92.1-99.3), and a specificity of 48.2 % (95 % CI 44.9-51.5) with a good prognostic accuracy (area under the ROC = 0.81; 95 % CI 0.78, 0.84). Subgroup analysis according to different age groups gives similar results. A simple RAM based on multiple domains, previously validated for predicting mortality of older adults within 1 year from the index hospitalization, can be useful at the moment of admission to Internal Medicine wards to accurately identify patients at low risk of in-hospital mortality.

摘要

入院的老年患者在住院期间及出院后死亡的风险均有所增加。住院死亡率风险评估模型(RAMs)主要基于生理变量和一些实验室数据,而晚期死亡率的RAMs通常包括残疾和合并症等其他领域。我们旨在评估先前验证的1年死亡率模型(沃尔特评分)在预测住院死亡率方面是否也能发挥良好作用。我们回顾性地查阅了2013年4月至12月在我们病房入院患者的病历。使用有关性别、日常生活活动能力(ADLs)、合并症和常规实验室检查的数据来计算改良沃尔特评分(MoWS)。主要结局指标是全因住院死亡率。分析涉及1004例患者。其中,888例存活出院,116例(11.5%)在住院期间死亡。整个样本的平均MoWS为4.9(±3.6)。分层为风险类别与住院死亡率平行(趋势卡方检验p<0.001)。当进行二分法时,MoWS的敏感性为97.4%(95%CI 92.1-99.3),特异性为48.2%(95%CI 44.9-51.5),具有良好的预后准确性(ROC曲线下面积=0.81;95%CI 0.78,0.84)。根据不同年龄组进行的亚组分析得出了类似的结果。一个基于多个领域的简单RAM,先前已验证可用于预测从指数住院起1年内老年人的死亡率,在入住内科病房时可用于准确识别住院死亡率低风险的患者。

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