骨膜蛋白和巨噬细胞在胶质母细胞瘤中的特殊作用。
A niche role for periostin and macrophages in glioblastoma.
机构信息
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
出版信息
Nat Cell Biol. 2015 Feb;17(2):107-9. doi: 10.1038/ncb3095.
DOI:10.1038/ncb3095
PMID:25633271
Abstract
Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice.
摘要
巨噬细胞促进肿瘤进展，但目前尚不清楚这种能力是否受肿瘤起始细胞的影响。研究表明，神经胶质瘤干细胞会分泌一种细胞外基质蛋白——骨膜蛋白，这种蛋白可以募集促肿瘤巨噬细胞，增强小鼠神经胶质瘤的进展。
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