[吩噻嗪类精神药物对胸腺细胞DNA基质活性及糖皮质激素受体相互作用的影响]
[Effects of psychotropic drugs of the phenothiazine series on matrix activity of thymocyte DNA and glucocorticoid receptor interactions].
作者信息
Golikov P P
出版信息
Biull Eksp Biol Med. 1989 Jan;107(1):56-8.
The experiment on adrenalectomized rats has shown that the concentration rates of 3.5.10(-4)M aminazine and 7.0.10(-4)M tizercine reduce 3H-acetonide triamcinolone-receptor interaction, and the concentration rate of 7.0.10(-4) tizercine increases 3H-cortisol receptor interaction in liver cytosol. The concentration rates of 3.5.10(-7)M aminazine and 3.5.10(-5)M tizercine suppress 3H-uridine inclusion into the acid-resisting mRNA thymocyte fraction. Associated introduction of aminazine and tizercine with acetonide triamcinolone (10(-8)M) increases the inhibiting effect on 3H-uridine inclusion into mRNA thymocytes. This suggests that aminazine and tizercine suppress matrix activity of DNA thymocytes through their effect on glucocorticoid receptors of type II.
对肾上腺切除大鼠的实验表明，3.5×10⁻⁴M氯丙嗪和7.0×10⁻⁴M替泽辛的浓度率降低了³H-丙酮化曲安西龙-受体相互作用，而7.0×10⁻⁴替泽辛的浓度率增加了肝细胞溶胶中³H-皮质醇受体相互作用。3.5×10⁻⁷M氯丙嗪和3.5×10⁻⁵M替泽辛的浓度率抑制了³H-尿苷掺入耐酸mRNA胸腺细胞部分。氯丙嗪和替泽辛与丙酮化曲安西龙（10⁻⁸M）联合引入增加了对³H-尿苷掺入mRNA胸腺细胞的抑制作用。这表明氯丙嗪和替泽辛通过对II型糖皮质激素受体的作用抑制DNA胸腺细胞的基质活性。
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