Taniguchi Hikari, Shiba Tomoaki, Maeno Takatoshi, Takahashi Mao
Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan.
Ophthalmologica. 2015;233(3-4):128-33. doi: 10.1159/000371716. Epub 2015 Jan 27.
To evaluate the risk factors for acute atherothrombotic events in patients with exudative age-related macular degeneration (AMD) without a history of coronary artery disease or stroke.
Two hundred fifty-nine patents with exudative AMD were evaluated for carotid atherosclerosis, peripheral arterial disease, and chronic kidney disease (CKD).
A mean intima-media thickness of ≥1.0 mm was found in 28.2% of patients; 8.9% of patients had severe carotid artery stenosis. The prevalence rates of severe atherosclerosis with a plaque score >10, peripheral arterial disease, and CKD were 16.6, 5.4, and 32%, respectively. Diabetes mellitus and AMD affecting eyes bilaterally were identified as risk factors for abnormal carotid artery thickening, and age and body mass index were identified as risk factors for CKD.
The current study confirmed that potentially 30% of patients with exudative AMD without a history of coronary artery disease or stroke have a high risk of acute atherothrombotic events.
评估无冠状动脉疾病或中风病史的渗出性年龄相关性黄斑变性（AMD）患者发生急性动脉粥样硬化血栓形成事件的风险因素。
对259例渗出性AMD患者进行颈动脉粥样硬化、外周动脉疾病和慢性肾脏病（CKD）评估。
28.2%的患者平均内膜中层厚度≥1.0 mm；8.9%的患者有严重颈动脉狭窄。斑块评分>10的严重动脉粥样硬化、外周动脉疾病和CKD的患病率分别为16.6%、5.4%和32%。糖尿病和双侧眼睛受累的AMD被确定为颈动脉异常增厚的风险因素，年龄和体重指数被确定为CKD的风险因素。
当前研究证实，无冠状动脉疾病或中风病史的渗出性AMD患者中，潜在有30%发生急性动脉粥样硬化血栓形成事件的风险较高。
