弗里德赖希共济失调与9号染色体连锁的确认及一个新的紧密连锁标记的鉴定。
Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker.
作者信息
Fujita R, Agid Y, Trouillas P, Seck A, Tommasi-Davenas C, Driesel A J, Olek K, Grzeschik K H, Nakamura Y, Mandel J L, Hanauer A
机构信息
U.184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.
出版信息
Genomics. 1989 Jan;4(1):110-1. doi: 10.1016/0888-7543(89)90323-6.
A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).
对33个患有弗里德赖希共济失调（FA）的家族进行了与9号染色体标记的连锁分析。S. Chamberlain等人（1988年，《自然》伦敦版334:248 - 249）先前确定的与D9S15的连锁在我们的样本中得到了证实（在θ = 0.02时，z(θ) = 6.82），而INFB（β - 干扰素基因）显示出较松散的连锁。另一个标记D9S5也被证明与FA紧密连锁（在θ = 0.00时，z(θ) = 5.77）。
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