DNA适配体门控膜

DNA-aptamer gating membranes.

作者信息

Schäfer Thomas, Özalp Veli Cengiz

机构信息

POLYMAT, University of the Basque Country, Av. Tolosa 72, 20018 Donostia-San Sebastián, Spain.

出版信息

Chem Commun (Camb). 2015 Mar 28;51(25):5471-4. doi: 10.1039/c4cc09660f.

DOI:10.1039/c4cc09660f

PMID:25633657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4840836/

Abstract

This report describes a membrane barrier whose permeability is modulated through the recognition of a small-molecule target, adenosine triphosphate (ATP), by a DNA-aptamer. The gating function of the DNA-aptamer in the stimulus-responsive membrane was shown to be specific, concentration dependent, and reversible.

摘要

本报告描述了一种膜屏障，其通透性通过DNA适配体对小分子靶标三磷酸腺苷（ATP）的识别来调节。DNA适配体在刺激响应膜中的门控功能表现出特异性、浓度依赖性和可逆性。