一锅法三组分芳基炔基砜的合成。
One-pot, three-component arylalkynyl sulfone synthesis.
作者信息
Chen C Chun, Waser Jerome
机构信息
Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
出版信息
Org Lett. 2015 Feb 6;17(3):736-9. doi: 10.1021/acs.orglett.5b00015. Epub 2015 Jan 29.
Abstract
A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.
摘要
报道了一种通过乙炔基苯碘酰酮（EBX）试剂、DABSO（DABCO·SO2）以及有机镁试剂或芳基碘化物与钯催化剂反应一锅法制备芳基磺酰基炔烃的三组分方案。以46 - 85%的总收率得到了多种芳基和杂芳基炔基砜。
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