小鼠白细胞介素-6基因定位于5号染色体的近端区域。
The murine Il-6 gene maps to the proximal region of chromosome 5.
作者信息
Mock B A, Nordan R P, Justice M J, Kozak C, Jenkins N A, Copeland N G, Clark S C, Wong G G, Rudikoff S
机构信息
Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892.
出版信息
J Immunol. 1989 Feb 15;142(4):1372-6.
Murine Il-6 cDNAs were isolated by cross-hybridization with a human IL-6 cDNA from an IL-1 activated bone marrow stromal cell line (W20). Mouse-hamster somatic cell hybrids were utilized to localize murine Il-6 to chromosome 5. Genetic mapping with respect to En-2, AlbH, and Gus in backcross progeny from an interspecific mating between C57BL/6J and Mus spretus positioned Il-6 3 cM distal to En-2. The syntenic relationships of Il-6 and En-2 in mouse and man, as well as the potential role of IL-6 in tumorigenesis, are discussed.
通过与来自白细胞介素-1激活的骨髓基质细胞系（W20）的人白细胞介素-6 cDNA进行交叉杂交，分离出小鼠白细胞介素-6 cDNA。利用小鼠-仓鼠体细胞杂种将小鼠白细胞介素-6定位于5号染色体。在C57BL/6J和小家鼠之间的种间杂交回交后代中，关于En-2、AlbH和Gus进行基因定位，结果将白细胞介素-6定位在En-2远端3 cM处。讨论了小鼠和人类中白细胞介素-6与En-2的同线关系，以及白细胞介素-6在肿瘤发生中的潜在作用。
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