Sölen G, Edgren M, Scott O C, Révész L
Department of Tumour Biology II, Karolinska Institute, Stockholm, Sweden.
Int J Radiat Biol. 1989 Feb;55(2):201-10. doi: 10.1080/09553008914550251.
After exposure to radiation in the presence of different oxygen concentrations, the OER values were determined for human fibroblasts cell strains with differing intrinsic GSH content, and cells depleted of GSH to different extent by treatment with BSO. The yield of DNA single-strand breaks was used as the measure of radiosensitivity. The K values were found to be related specifically to the GSH concentration in the cell nuclei. A good agreement was found between the experimental observations and the prediction of a variant of the competition model in which a second type of damage, not influenced by oxygen, was included.
在不同氧浓度条件下暴露于辐射后，测定了具有不同内在谷胱甘肽（GSH）含量的人成纤维细胞系以及通过丁硫氨酸亚砜胺（BSO）处理使GSH不同程度耗竭的细胞的氧增强比（OER）值。DNA单链断裂的产率用作放射敏感性的度量。发现K值与细胞核中的GSH浓度具有特定关系。实验观察结果与包含不受氧影响的第二种损伤类型的竞争模型变体的预测之间发现了良好的一致性。
