Duckworth Ralph M, Jones S
Centre for Oral Health Research, School of Dental Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
Caries Res. 2015;49(2):141-6. doi: 10.1159/000365949. Epub 2015 Jan 27.
The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.
使用牙膏、漱口水等后口腔中保留的氟化物量对于确定它们的防龋效果可能很重要。在本研究中，我们调查了唾液流速与唾液氟清除率之间的关系。10名成年人以随机顺序测试了6种漱口水，包括添加和未添加氯化钠（1.28 mol/l）或蔗糖（0.44 mol/l）的氟化钠水溶液（0.013、0.026 mol/l）。在每次测试前，受试者吞咽，用2 ml水漱口2分钟，然后吐入一个预先称重的容器中以获得初始唾液流速的测量值。接下来，使用其中一种测试漱口水重复该过程。最后，在每次使用漱口水后长达3小时收集非刺激性全唾液样本并分析氟化物。与使用不含任何添加剂的相应漱口水相比，使用含有蔗糖或氯化钠的漱口水后唾液氟浓度显著降低，这两种化合物均显著增加了唾液流速。唾液氟清除曲线下面积（AUC）值在个体水平上与唾液流速呈负相关（p < 0.01）。观察到的行为不能完全归因于应用时唾液的稀释作用。
