Kumar Pankaj, Murakami Masanao, Kaul Rajeev, Saha Abhik, Cai Qiliang, Robertson Erle S
Department of Microbiology & The Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, PA, USA.
Department of Microbiology & The Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, 201E Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA, Tel.: +1 215 746 0114;
Future Virol. 2009 Jan;4(1):79-91. doi: 10.2217/17460794.4.1.79.
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with a large number of lymphoid and epithelial malignancies. As a successful pathogen it has co-evolved with its human host for millions of years. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, a small subset of viral proteins is expressed. These proteins are essential for maintenance of the EBV genome as well as the deregulation of various signaling pathways that facilitate the proliferation and survival of the infected cells. Epstein-Barr nuclear antigen (EBNA)3C is one of the latent proteins shown to be essential for transformation of primary human B lymphocytes . EBNA3C primarily functions as a transcriptional regulator by interacting with a number of well known cellular and viral transcriptional factors. We have recently identified several binding partners for EBNA3C including proteins that regulate cell cycle and chromatin remodeling. We are actively engaged in discerning the biological significance of these interactions. This review summarizes our current understanding of how EBNA3C usurps cellular pathways that promote B-cell transformation.
爱泼斯坦-巴尔病毒（EBV）是一种普遍存在的人类疱疹病毒，与大量淋巴和上皮恶性肿瘤相关。作为一种成功的病原体，它已经与人类宿主共同进化了数百万年。EBV具有在原代人类B淋巴细胞中建立终身潜伏感染的独特能力。在潜伏感染期间，一小部分病毒蛋白会表达。这些蛋白对于维持EBV基因组以及失调促进受感染细胞增殖和存活的各种信号通路至关重要。爱泼斯坦-巴尔核抗原（EBNA）3C是一种潜伏蛋白，已被证明对原代人类B淋巴细胞的转化至关重要。EBNA3C主要通过与许多知名的细胞和病毒转录因子相互作用来发挥转录调节因子的作用。我们最近鉴定了EBNA3C的几个结合伙伴，包括调节细胞周期和染色质重塑的蛋白。我们正在积极致力于识别这些相互作用的生物学意义。这篇综述总结了我们目前对EBNA3C如何篡夺促进B细胞转化的细胞途径的理解。
