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急诊科对一名左心房肉瘤患者的肺动脉高压诊断。

Emergency department diagnosis of pulmonary hypertension in a patient with left atrial sarcoma.

作者信息

Dela Cruz Maricel, Devey Jeremy Seelinger

机构信息

Aria Health Philadelphia, Philadelphia 19124, PA, USA.

Gallup Indian Medical Center, Gallup 87301, NM, USA.

出版信息

Int J Emerg Med. 2014 Sep 30;7:32. doi: 10.1186/s12245-014-0032-5. eCollection 2014.

DOI:10.1186/s12245-014-0032-5
PMID:25635192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4306056/
Abstract

Pulmonary hypertension is a disease with many etiologies and is responsible for 200,000 admissions and 25,000 hospitalizations in the United States each year. We report the case of a previously healthy 58-year-old woman who presented to the emergency department with a months-long history of worsening dyspnea on exertion, orthopnea, and paroxysmal nocturnal dyspnea. Despite the severity of her symptoms, she had no corroborative physical exam findings, including jugular venous distension or peripheral edema. Bedside emergency department ultrasonography revealed a dilated right ventricle and bowing of the intraventricular septum into the left ventricle, consistent with pulmonary hypertension. CT angiography of the chest performed in the emergency department revealed a large left atrial mass, found on pathology to be a left atrial sarcoma. This case illustrates how severely symptomatic pulmonary hypertension can have few to no physical exam findings and the utility of bedside emergency department ultrasound in making the presumptive diagnosis.

摘要

肺动脉高压是一种病因多样的疾病,在美国每年导致20万例入院治疗和2.5万例住院治疗。我们报告了一例此前健康的58岁女性病例,她因进行性加重的劳力性呼吸困难、端坐呼吸和阵发性夜间呼吸困难长达数月而就诊于急诊科。尽管她症状严重,但体格检查未发现支持性体征,包括颈静脉怒张或外周水肿。急诊科床边超声检查显示右心室扩张,室间隔向左心室膨出,符合肺动脉高压表现。在急诊科进行的胸部CT血管造影显示左心房有一个大肿块,病理检查发现是左心房肉瘤。该病例说明了症状严重的肺动脉高压在体格检查中可能几乎没有或完全没有体征,以及急诊科床边超声在做出初步诊断方面的作用。

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本文引用的文献

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Case records of the Massachusetts General Hospital. Case 9-2014. A 34-year-old woman with increasing dyspnea.马萨诸塞州总医院病例记录。病例9 - 2014。一名34岁呼吸困难加重的女性。
N Engl J Med. 2014 Mar 20;370(12):1149-57. doi: 10.1056/NEJMcpc1305992.
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Macitentan and morbidity and mortality in pulmonary arterial hypertension.马西替坦治疗肺动脉高压的发病率和死亡率。
N Engl J Med. 2013 Aug 29;369(9):809-18. doi: 10.1056/NEJMoa1213917.
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Right ventricular function predicts clinical response to specific vasodilator therapy in patients with pulmonary hypertension.
右心室功能可预测肺动脉高压患者对特定血管扩张剂治疗的临床反应。
Echocardiography. 2013 Jan;30(1):17-26. doi: 10.1111/j.1540-8175.2012.01809.x. Epub 2012 Sep 18.
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Robotic excision of atrial myxoma.心房黏液瘤的机器人切除术。
J Card Surg. 2012 Jul;27(4):423-6. doi: 10.1111/j.1540-8191.2012.01478.x. Epub 2012 May 29.
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Primary cardiac angiosarcoma treated by complete tumor resection with cardiac reconstruction.原发性心脏血管肉瘤经完全肿瘤切除和心脏重建治疗。
Heart Lung. 2011 May-Jun;40(3):e41-3. doi: 10.1016/j.hrtlng.2010.07.006.
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Surgical resection of atrial myxomas.心房黏液瘤的手术切除
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7
Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension.用于治疗肺动脉高压的5型磷酸二酯酶抑制剂。
N Engl J Med. 2009 Nov 5;361(19):1864-71. doi: 10.1056/NEJMct0904473.
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12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism.12 导联心电图在肺动脉高压的发现中,在有肺栓塞的急诊科患者中比在没有肺栓塞的患者中更为常见。
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Cardiovasc Ultrasound. 2009 Sep 8;7:45. doi: 10.1186/1476-7120-7-45.
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ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association.美国心脏病学会基金会专家共识文件工作组与美国心脏协会合作制定的2009年ACCF/AHA肺动脉高压专家共识文件,与美国胸科医师学会、美国胸科学会以及肺动脉高压协会共同完成。
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