Tang Jun-Nan, Shen De-Liang, Liu Cong-Lin, Wang Xiao-Fang, Zhang Li, Xuan Xue-Xi, Cui Ling-Ling, Zhang Jin-Ying
Department of Cardiology (J-NT, D-LS, C-LL, X-FW, LZ, X-XX, J-YZ), the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Institute of Clinical Medicine (J-NT), the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; and College of Public Health (L-LC), Zhengzhou University, Zhengzhou, China.
Am J Med Sci. 2015 Feb;349(2):130-6. doi: 10.1097/MAJ.0000000000000378.
C1q/TNF-related protein 1 (CTRP-1), a novel adipocyte factor, may participate in the mechanisms of metabolism and inflammation. Interleukin 6 (IL-6) is a proinflammatory cytokine that is correlated with the severity of coronary heart disease (CHD). In this study, we focused on the levels of CTRP-1 and IL-6 in patients with CHD.
Circulating CTRP-1 and IL-6 levels were measured using enzyme-linked immunosorbent assay in 81 patients with acute coronary syndrome (n=41) or stable angina pectoris (n=40). CTRP-1 and IL-6 levels were also examined in 30 healthy individuals (control group). We examined the correlations between the levels of CTRP-1 and IL-6 and cardiac risk factors in CHD. Logistic regression analysis was performed to screen for factors that predict CHD.
Both CTRP-1 and IL-6 concentrations were increased in the acute coronary syndrome or stable angina pectoris group compared with the control group (P<0.01). Both plasma levels of CTRP-1 and IL-6 in the single-, double- and triple-vessel lesion group were higher compared with the control group (P<0.01). CTRP-1 levels were positively correlated with IL-6 (r=0.667, P<0.01) and high-sensitivity C-reactive protein levels (r=0.520, P<0.01) and negatively correlated with HDL-C (r=-0.432, P<0.01). The logistic regression analysis showed that increases in CTRP-1 and IL-6 levels may be powerful predictors of CHD.
The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. This potential suggests that evaluating CTRP-1 and IL-6 in combination may aid in predicting the occurrence of CHD.
C1q/TNF相关蛋白1（CTRP-1）是一种新型脂肪细胞因子，可能参与代谢和炎症机制。白细胞介素6（IL-6）是一种促炎细胞因子，与冠心病（CHD）的严重程度相关。在本研究中，我们关注冠心病患者的CTRP-1和IL-6水平。
采用酶联免疫吸附测定法测量81例急性冠脉综合征患者（n = 41）或稳定型心绞痛患者（n = 40）的循环CTRP-1和IL-6水平。还检测了30名健康个体（对照组）的CTRP-1和IL-6水平。我们研究了冠心病患者中CTRP-1和IL-6水平与心脏危险因素之间的相关性。进行逻辑回归分析以筛选预测冠心病的因素。
与对照组相比，急性冠脉综合征或稳定型心绞痛组的CTRP-1和IL-6浓度均升高（P < 0.01）。单支、双支和三支血管病变组的血浆CTRP-1和IL-6水平均高于对照组（P < 0.01）。CTRP-1水平与IL-6呈正相关（r = 0.667，P < 0.01），与高敏C反应蛋白水平呈正相关（r = 0.520，P < 0.01），与高密度脂蛋白胆固醇呈负相关（r = -0.432，P < 0.01）。逻辑回归分析表明，CTRP-1和IL-6水平升高可能是冠心病的有力预测指标。
血浆CTRP-1和IL-6浓度的变化可能在反映冠心病炎症程度和冠状动脉粥样硬化严重程度方面起重要作用。这一潜力表明，联合评估CTRP-1和IL-6可能有助于预测冠心病的发生。
