绝经后髋部骨折女性的血清25-羟维生素D水平与功能转归
Serum levels of 25-hydroxyvitamin D and functional outcome among postmenopausal women with hip fracture.
作者信息
Liu Lan-Mei, Wang Shuai-Hua, Fu Chuan-Sheng, Han Xiang-Zhen, Wei Bao-Fu
机构信息
Department of Orthopedics, Linyi People's Hospital, Linyi, Shandong province, People's Republic of China.
Hand and Foot Surgery Department, Shandong Provincial Hospital, Jinan, Shandong province, People's Republic of China.
出版信息
PLoS One. 2015 Jan 30;10(1):e0116375. doi: 10.1371/journal.pone.0116375. eCollection 2015.
OBJECTIVE
The main objective of the current study was to assess the distribution and its prognostic value of serum 25-hydroxyvitamin D (25[OH] D) levels assessed at admission in Chinese postmenopausal women with hip fracture.
METHODS
From January 1, 2012 to December 31, 2013, all postmenopausal women with first-ever hip fracture were recruited to participate in the study. Serum 25[OH] D levels were measured at admission. The functional evaluation at the time of discharge was performed by the Barthel Index (BI). The prognostic value of 25[OH] D to predict the functional outcome within discharge was analyzed by logistic regression analysis, after adjusting for the possible confounders.
RESULTS
In our study, 261 patients were included and assessed. In the 76 patients with an unfavorable functional outcome, serum 25(OH) D levels were lower compared with those in patients with a favorable outcome [11.8(IQR, 9.9-16.1) ng/ml; 16.8(IQR, 13.6-21.4) ng/ml, respectively; P<0.0001]. In multivariate analysis, there was an increased risk of unfavorable outcome associated with serum 25(OH) D levels ≤ 20 ng/ml (OR 5.24, 95%CI: 3.11-8.15; P<0.0001) after adjusting for possible confounders.
CONCLUSIONS
Our data support an association between serum 25[OH] D levels and prognosis in Chinese postmenopausal women with hip fracture.
目的
本研究的主要目的是评估中国绝经后髋部骨折女性入院时血清25-羟基维生素D（25[OH]D）水平的分布及其预后价值。
方法
2012年1月1日至2013年12月31日，招募所有首次发生髋部骨折的绝经后女性参与本研究。入院时测量血清25[OH]D水平。出院时通过巴氏指数（BI）进行功能评估。在调整可能的混杂因素后，通过逻辑回归分析分析25[OH]D对出院时功能结局的预测预后价值。
结果
本研究纳入并评估了261例患者。在76例功能结局不佳的患者中，血清25(OH)D水平低于功能结局良好的患者[分别为11.8（四分位间距，9.9 - 16.1）ng/ml；16.8（四分位间距，13.6 - 21.4）ng/ml；P<0.0001]。在多变量分析中，调整可能的混杂因素后，血清25(OH)D水平≤20 ng/ml与不良结局风险增加相关（比值比5.24，95%置信区间：3.11 - 8.15；P<0.0001）。
结论
我们的数据支持中国绝经后髋部骨折女性血清25[OH]D水平与预后之间存在关联。
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