Gao HeLi, Guan Mei, Sun Zhao, Bai ChunMei
Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China,
Tumour Biol. 2015 Feb;36(2):515-20. doi: 10.1007/s13277-014-2659-5. Epub 2015 Jan 31.
Recent studies have shown that c-Met is an important signal in the development of colorectal cancer, but the prognostic value of c-Met remains unclear. We aimed to analyze the prognostic effect of c-Met in colorectal cancer through a systematic review and meta-analysis. Through database searches, we identified six articles describing how c-Met status affects colorectal cancer prognosis. A meta-analysis was performed to investigate the relationship between the hazard ratio and survival. The available outcome data from six articles were examined. A meta-analysis of the HR and the 95% confidence interval (CI) indicated a significantly poor overall survival and disease-free survival in patients with high expression levels of c-Met. The subgroup analysis showed that the prognostic effect of the c-Met level was similar in different methods and was not associated with disease stages. High c-Met expression levels could predict a poor prognosis in colorectal cancer patients. The c-Met status could be used to evaluate the prognosis in clinical patients.
近期研究表明，c-Met是结直肠癌发生发展过程中的一个重要信号，但c-Met的预后价值仍不明确。我们旨在通过系统评价和荟萃分析来分析c-Met在结直肠癌中的预后作用。通过数据库检索，我们识别出6篇描述c-Met状态如何影响结直肠癌预后的文章。进行荟萃分析以研究风险比与生存率之间的关系。对这6篇文章中可得的结局数据进行了审查。对风险比（HR）和95%置信区间（CI）的荟萃分析表明，c-Met高表达水平的患者总生存期和无病生存期显著较差。亚组分析显示，不同方法中c-Met水平的预后作用相似，且与疾病分期无关。c-Met高表达水平可预测结直肠癌患者预后不良。c-Met状态可用于评估临床患者的预后。
