Wan Xiangxiang, Ding Xiaoyun, Chen Shengcan, Song Haojun, Jiang Haizhong, Fang Ying, Li Peifei, Guo Junming
Department of Gastroenterology, Ningbo First Hospital, No. 59 Liuting Street, Ningbo, 315010, China.
Tumour Biol. 2015 Feb;36(2):521-32. doi: 10.1007/s13277-015-3136-5. Epub 2015 Feb 1.
Gastric cancer is one of the most common malignant diseases and has one of the highest mortality rates worldwide. Its molecular mechanisms are poorly understood. Recently, the functions of non-coding RNAs (ncRNAs) in gastric cancer have attracted wide attention. Although the expression levels of various ncRNAs are different, they may work together in a network and contribute to gastric carcinogenesis by altering the expression of oncogenes or tumor suppressor genes. They affect the cell cycle, apoptosis, motility, invasion, and metastasis. Dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), including miR-21, miR-106, H19, and ANRIL, directly or indirectly regulate carcinogenic factors or signaling pathways such as PTEN, CDK, caspase, E-cadherin, Akt, and P53. Greater recognition of the roles of miRNAs and lncRNAs in gastric carcinogenesis can provide new insight into the mechanisms of tumor development and identify targets for anticancer drug development.
胃癌是最常见的恶性疾病之一，也是全球死亡率最高的疾病之一。其分子机制尚不清楚。近年来，非编码RNA（ncRNAs）在胃癌中的功能引起了广泛关注。尽管各种ncRNAs的表达水平不同，但它们可能在一个网络中共同发挥作用，并通过改变癌基因或抑癌基因的表达来促进胃癌的发生。它们影响细胞周期、凋亡、运动、侵袭和转移。失调的微小RNA（miRNAs）和长链非编码RNA（lncRNAs），包括miR-21、miR-106、H19和ANRIL，直接或间接调节致癌因子或信号通路，如PTEN、CDK、半胱天冬酶、E-钙黏蛋白、Akt和P53。对miRNAs和lncRNAs在胃癌发生中作用的更多认识可以为肿瘤发展机制提供新的见解，并确定抗癌药物开发的靶点。
