Rocha Hermano Alexandre Lima, Silva Anamaria Cavalcante E, Correia Luciano Lima, Campos Jocileide Sales, Machado Márcia Maria Tavares, Leite Álvaro Jorge Madeiro, da Cunha Antonio Jose Ledo Alves
Department of Public Health, Universidade Federal do Ceará, Rua Prof Costa Mendes, 1609, Fortaleza, CE, 60430-130, Brazil,
Matern Child Health J. 2015 Jul;19(7):1652-6. doi: 10.1007/s10995-015-1676-3.
The present study aimed to determine the prevalence of supplementation between 1987 and 2007, and to measure the impact of this on morbidity. Five sequential cross-sectional studies in a 20-year time span were analyzed. Each had a sample of 8,000 domiciles representative of Ceará, in northeastern Brazil. Data were analyzed with descriptive statistics, followed by bivariate and multivariate analyses. Increases in coverage, ranging from 9.6 to 65.8 % were verified, and the study found that the impact of supplementation in reducing morbidity may not be significant. The study also found that supplementation may be associated with higher frequency of certain morbidities (OR 1.8, CI 95 % 1.20-2.95). When the supplementation variable was adjusted for socioeconomic factors, the risk was higher for diarrhea (OR 5.56, CI 95 % 2.63-11.75). The study concluded that in Brazil, vitamin A supplementation may have little benefit in reducing morbidity.
本研究旨在确定1987年至2007年间补充剂的使用情况，并衡量其对发病率的影响。分析了20年时间跨度内的五项连续横断面研究。每项研究都有来自巴西东北部塞阿拉州的8000个具有代表性的家庭样本。数据采用描述性统计分析，随后进行双变量和多变量分析。研究发现覆盖率从9.6%提高到了65.8%，但补充剂在降低发病率方面的影响可能并不显著。该研究还发现，补充剂可能与某些疾病的较高发病率相关（比值比1.8，95%置信区间1.20 - 2.95）。当对补充剂变量进行社会经济因素调整后，腹泻的风险更高（比值比5.56，95%置信区间2.63 - 11.75）。该研究得出结论，在巴西，补充维生素A对降低发病率可能益处不大。
