Sutliffe Jay T, Wilson Lori D, de Heer Hendrik D, Foster Ray L, Carnot Mary Jo
Northern Arizona University, College of Health & Human Services, PO Box 15095, Flagstaff, AZ 86011, United States.
Northern Arizona University, College of Health & Human Services, PO Box 15095, Flagstaff, AZ 86011, United States.
Complement Ther Med. 2015 Feb;23(1):32-7. doi: 10.1016/j.ctim.2014.11.001. Epub 2014 Dec 3.
This brief lifestyle intervention, including a vegan diet rich in fresh fruits and vegetables, whole grains and various legumes, nuts and seeds, significantly improved health risk factors and reduced systemic inflammation as measured by circulating CRP. The degree of improvement was associated with baseline CRP such that higher levels predicted greater decreases. The interaction between gender and baseline CRP was significant and showed that males with higher baseline CRP levels appeared to have a more robust decrease in CRP due to the intervention than did their female counterparts. It is likely that the vegetable and high fiber content of a vegan diet reduces CRP in the presences of obesity. Neither the quantity of exercise nor the length of stay was significant predictors of CRP reduction. Additionally, those participants who had a vegan diet prior to the intervention had the lowest CRP risk coming into the program. Direct measure of body fat composition, estrogen and other inflammatory mediators such as IL-6 and TNF-alpha would enhance current understanding of the specific mechanisms of CRP reduction related to lifestyle interventions.
这种简短的生活方式干预，包括富含新鲜水果和蔬菜、全谷物、各种豆类、坚果和种子的纯素饮食，显著改善了健康风险因素，并降低了通过循环CRP测量的全身炎症。改善程度与基线CRP相关，因此较高水平预示着更大幅度的下降。性别与基线CRP之间的相互作用显著，表明基线CRP水平较高的男性由于干预导致的CRP下降似乎比女性更明显。纯素饮食中的蔬菜和高纤维含量可能在存在肥胖的情况下降低CRP。运动的量和停留的时间都不是CRP降低的显著预测因素。此外，那些在干预前食用纯素饮食的参与者进入该项目时CRP风险最低。直接测量身体脂肪组成、雌激素和其他炎症介质如IL-6和TNF-α将增强目前对与生活方式干预相关的CRP降低的具体机制的理解。
