Merrill Ray M, Massey Michael T, Aldana Steven G, Greenlaw Roger L, Diehl Hans A, Salberg Audrey
Brigham Young University, Department of Health Science, Provo, UT 84604, USA.
Prev Med. 2008 May;46(5):425-30. doi: 10.1016/j.ypmed.2007.12.002. Epub 2007 Dec 8.
To identify whether the Coronary Health Improvement Project (CHIP), an intervention designed to increase physical activity and improve diet, lowers serum C-reactive protein (CRP). The study will also assess whether changes in CRP over the study period are associated with baseline levels of and changes in selected coronary risk factors.
A randomized controlled study design assigned 348 individuals to the intervention or control group with measurements taken at baseline, 6 weeks, and 6 months of body weight, physical activity, and serum CRP levels. Participants attended an intensive 40-hour educational course delivered over a 4-week period, beginning March 2003, in Rockford, IL, USA.
The intervention significantly increased physical activity and decreased BMI, weight, percent body fat, and saturated fat (P<0.0001). However, the intervention was not significantly associated with a decrease in CRP. Participants in both the intervention and control groups combined showed a decrease in high CRP (>3 mg/L), from 46% at baseline to 38% at 6 weeks and 41% at 6 months. Those with higher BMI at baseline showed a greater increase in CRP over time (P<0.0001), whereas those with higher CRP at baseline showed a greater decrease in CRP over time (P<0.0001).
Over 6 week and 6 month follow-up periods, the intervention failed to discriminate changes in CRP. However, the percentage with high CRP did fall, more so for those with lower BMI and higher CRP at baseline. BMI may mediate the influence of physical activity on CRP.
确定旨在增加身体活动和改善饮食的冠状动脉健康改善项目（CHIP）是否能降低血清C反应蛋白（CRP）。该研究还将评估研究期间CRP的变化是否与选定的冠状动脉危险因素的基线水平及变化相关。
一项随机对照研究设计将348名个体分为干预组或对照组，并在基线、6周和6个月时测量体重、身体活动及血清CRP水平。参与者于2003年3月开始在美国伊利诺伊州罗克福德参加了为期4周、共40小时的强化教育课程。
干预显著增加了身体活动，并降低了体重指数、体重、体脂百分比和饱和脂肪（P<0.0001）。然而，干预与CRP的降低并无显著关联。干预组和对照组的参与者合起来显示，高CRP（>3mg/L）的比例有所下降，从基线时的46%降至6周时的38%和6个月时的41%。基线时体重指数较高的人CRP随时间的增加幅度更大（P<0.0001），而基线时CRP较高的人CRP随时间的下降幅度更大（P<0.0001）。
在6周和6个月的随访期内，干预未能区分CRP的变化。然而，高CRP的百分比确实下降了，对于基线时体重指数较低且CRP较高的人来说下降幅度更大。体重指数可能介导身体活动对CRP的影响。
