Ried Karin
National Institute of Integrative Medicine, Hawthorn, Melbourne, VIC, Australia.
Complement Ther Med. 2015 Feb;23(1):116-28. doi: 10.1016/j.ctim.2014.12.004. Epub 2015 Jan 3.
To assess the effect of Traditional Chinese herbal medicine (CHM) in the management of female infertility and on pregnancy rates compared with Western medical (WM) treatment and update previous meta-analyses.
We searched the Medline and Cochrane databases until December 2013 for randomized controlled trials and meta-analyses investigating Chinese herbal medicine therapy for female infertility and compared clinical pregnancy rates achieved with CHM versus WM drug treatment.
Forty RCTs involving 4247 women with infertility were included in our systematic review. Meta-analysis suggested a 1.74 higher probability of achieving a pregnancy with CHM therapy than with WM therapy alone (risk ratio 1.74, 95%CI: 1.56-1.94; p<0.0001; odds ratio 3.14; 95%CI: 2.72-3.62; p<0.0001) in women with infertility. Trials included women with PCOS, endometriosis, anovulation, fallopian tube blockage, or unexplained infertility. Mean pregnancy rates in the CHM group were 60% compared with 33% in the WM group.
Our review suggests that management of female infertility with Chinese herbal medicine can improve pregnancy rates 2-fold within a 3-6 month period compared with Western medical fertility drug therapy. In addition, fertility indicators such as ovulation rates, cervical mucus score, biphasic basal body temperature, and appropriate thickness of the endometrial lining were positively influenced by CHM therapy, indicating an ameliorating physiological effect conducive for a viable pregnancy.
评估中药在女性不孕症治疗中的效果以及与西医治疗相比的妊娠率，并更新以往的荟萃分析。
我们检索了截至2013年12月的Medline和Cochrane数据库，以查找调查中药治疗女性不孕症的随机对照试验和荟萃分析，并比较中药与西医药物治疗的临床妊娠率。
我们的系统评价纳入了40项涉及4247名不孕女性的随机对照试验。荟萃分析表明，在不孕女性中，中药治疗组的妊娠概率比单纯西医治疗组高1.74倍（风险比1.74，95%置信区间：1.56 - 1.94；p<0.0001；优势比3.14；95%置信区间：2.72 - 3.62；p<0.0001）。试验纳入了患有多囊卵巢综合征、子宫内膜异位症、无排卵、输卵管堵塞或不明原因不孕的女性。中药组的平均妊娠率为60%，而西医组为33%。
我们的综述表明，与西医生育药物治疗相比，中药治疗女性不孕症可在3 - 6个月内将妊娠率提高两倍。此外，排卵率、宫颈黏液评分、双相基础体温和子宫内膜适当厚度等生育指标受中药治疗的积极影响，表明其具有改善生理效应，有利于实现可行妊娠。
