Sreedharanunni Sreejesh, Varma Neelam, Sachdeva Man Updesh Singh, Gupta Kirti, Pai Rekha, Kochhar Rakesh, Malhotra Pankaj, Varma Subhash
Department of Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), V Floor, SS Anand Block (Research Block A), Chandigarh, 160012, India,
Int J Hematol. 2015 Jun;101(6):603-7. doi: 10.1007/s12185-015-1736-x. Epub 2015 Jan 31.
Indolent γδ T cell lymphomas/leukemias are rare and overlap with the morphological spectrum of large granular lymphocyte (LGL) leukemia. We report an extremely rare case of CD103(+) γδ T LGL leukemia in a patient with celiac disease who presented with refractory diarrhea. Whether the refractory diarrhea in our patient was a manifestation of LGL leukemia itself or whether the clonal LGL expansion is a manifestation of refractory celiac disease (RCD) remains an enigma. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with RCD.
惰性γδ T细胞淋巴瘤/白血病较为罕见，在形态学上与大颗粒淋巴细胞（LGL）白血病有重叠。我们报告了1例极为罕见的CD103(+)γδ T LGL白血病病例，患者为乳糜泻，伴有难治性腹泻。我们患者的难治性腹泻是LGL白血病本身的表现，还是克隆性LGL扩增是难治性乳糜泻（RCD）的表现，仍是个谜。本报告强调了在对RCD患者的克隆性CD103(+)淋巴细胞增多进行分类时的诊断困难及达成共识的必要性。
