利用扩散张量磁共振成像对色素性视网膜炎患者视辐射的改变情况进行研究。
Alteration of the optic radiations using diffusion-tensor MRI in patients with retinitis pigmentosa.
作者信息
Ohno Naonori, Murai Hideki, Suzuki Yukihisa, Kiyosawa Motohiro, Tokumaru Aya M, Ishii Kenji, Ohno-Matsui Kyoko
机构信息
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Kiyosawa Eye Clinic, Tokyo, Japan.
出版信息
Br J Ophthalmol. 2015 Aug;99(8):1051-4. doi: 10.1136/bjophthalmol-2014-305809. Epub 2015 Jan 30.
PURPOSE
To evaluate alteration of the optic radiation (OR) in patients with retinitis pigmentosa (RP) using fractional anisotropy (FA) measured by diffusion tensor MRI.
METHODS
We performed MRI and evaluated alteration of the ORs in 17 patients with RP and 27 healthy controls. Regions of interest were placed over the bilateral anterior and posterior areas of the ORs, and we measured the FA value of each region. Visual field (VF) tests were examined in all subjects, and we corrected the residual VF area according to the projection area to the striate cortex. Differences between the FA values of patients and healthy controls were tested. We performed regression analyses between the sum of the corrected VF areas and FA values in the anterior or posterior contralateral ORs in patients with RP. Moreover, we performed regression analyses between the average of FA values of ORs and the average of both eyes of visual acuity in patients with RP.
RESULTS
FA values of the bilateral anterior and posterior ORs were lower in patients with RP (anterior right, p=0.012; posterior right, p=0.0004; anterior left, p=0.0008; and posterior left, p=0.0004) compared with those of healthy controls. In patients with RP, significant correlations were observed between average FA values of anterior ORs and average visual acuity (correlation coefficient (r)=-0.54; p=0.025).
CONCLUSIONS
In patients with RP, alterations may occur not only in the retina but also in the brain.
目的
使用扩散张量磁共振成像测量的分数各向异性（FA）来评估视网膜色素变性（RP）患者的视辐射（OR）改变。
方法
我们对17例RP患者和27名健康对照者进行了磁共振成像，并评估了OR的改变。在双侧OR的前部和后部区域设置感兴趣区，测量每个区域的FA值。对所有受试者进行视野（VF）测试，并根据投射到纹状皮质的面积校正残余VF面积。测试患者和健康对照者FA值之间的差异。我们对RP患者对侧OR前部或后部校正VF面积总和与FA值进行回归分析。此外，我们对RP患者OR的FA值平均值与双眼视力平均值进行回归分析。
结果
与健康对照者相比，RP患者双侧OR前部和后部的FA值较低（右侧前部，p = 0.012；右侧后部，p = 0.0004；左侧前部，p = 0.0008；左侧后部，p = 0.0004）。在RP患者中，观察到OR前部的平均FA值与平均视力之间存在显著相关性（相关系数（r）=-0.54；p = 0.025）。
结论
在RP患者中，不仅视网膜可能发生改变，大脑也可能发生改变。
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