新生期处理（恢复力）可减轻大鼠因水回避应激诱导的慢性机械性痛觉过敏增强。
Neonatal handling (resilience) attenuates water-avoidance stress induced enhancement of chronic mechanical hyperalgesia in the rat.
作者信息
Alvarez Pedro, Levine Jon D, Green Paul G
机构信息
Departments of Oral and Maxillofacial Surgery, University of California, San Francisco, USA; Division of Neuroscience, University of California, San Francisco, USA.
Departments of Oral and Maxillofacial Surgery, University of California, San Francisco, USA; Departments of Medicine, University of California, San Francisco, USA; Division of Neuroscience, University of California, San Francisco, USA.
出版信息
Neurosci Lett. 2015 Mar 30;591:207-211. doi: 10.1016/j.neulet.2015.01.066. Epub 2015 Jan 28.
Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male rats underwent the handling protocol on postnatal days 2-9, weaned at 21 days and tested for muscle mechanical nociceptive threshold at postnatal days 50-75. Decrease in mechanical nociceptive threshold in skeletal muscle in adult rats, produced by exposure to water-avoidance stress, was significantly attenuated by neonatal handling. Neonatal handling also attenuated the mechanical hyperalgesia produced by intramuscular administration of the pronociceptive inflammatory mediator, prostaglandin E2 in rats exposed as adults to water-avoidance stress. Neonatal handling, which induces a smaller corticosterone response in adult rats exposed to a stressor as well as changes in central nervous system neurotransmitter systems, attenuates mechanical hyperalgesia produced by water-avoidance stress and enhanced prostaglandin hyperalgesia in adult animals.
众所周知，慢性应激会加剧疼痛。我们检验了这样一个假设：新生鼠抚触通过提高母性照料的质量和数量来诱导对压力负面影响的恢复力，从而减轻成年大鼠因避水应激产生的机械性痛觉过敏。新生雄性大鼠在出生后第2至9天接受抚触方案，21天断奶，并在出生后第50至75天测试肌肉机械性伤害感受阈值。成年大鼠因暴露于避水应激而导致的骨骼肌机械性伤害感受阈值降低，通过新生鼠抚触得到了显著减轻。新生鼠抚触还减轻了成年后暴露于避水应激的大鼠在肌肉注射促痛性炎症介质前列腺素E2后产生的机械性痛觉过敏。新生鼠抚触在成年大鼠暴露于应激源时会诱导较小的皮质酮反应以及中枢神经系统神经递质系统的变化，它减轻了成年动物因避水应激产生的机械性痛觉过敏，并增强了前列腺素痛觉过敏。
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