Roy-Chowdhuri Sinchita, Krishnamurthy Savitri
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 053, Houston, TX 77030-4095.
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 053, Houston, TX 77030-4095.
Semin Diagn Pathol. 2015 Jul;32(4):250-7. doi: 10.1053/j.semdp.2014.12.006. Epub 2014 Dec 19.
Enlarged neck lymph nodes are very often subject to fine needle aspiration biopsy to detect metastatic disease in patients with suspected or proven squamous cell carcinoma in head and neck region. Cytology specimens of metastatic carcinoma in such patients are routinely evaluated for human papilloma virus (HPV) to identify patients with HPV-related head and neck squamous cell carcinoma. Different types of cytology specimens including smears, cytospins, cell blocks and aspirated material in the rinse can all be used for different types of HPV testing such as immunohistochemistry for p16, HPV-in situ hybridization, and HPV-Polymerase chain reaction. There is currently no consensus regarding the testing of high-risk HPV in cytology specimens. The establishment of standardized HPV testing of cytology specimens is of utmost importance and is eagerly awaited.
对于疑似或已确诊头颈部鳞状细胞癌的患者，肿大的颈部淋巴结常需进行细针穿刺活检以检测转移性疾病。此类患者转移性癌的细胞学标本通常会进行人乳头瘤病毒（HPV）评估，以识别HPV相关的头颈部鳞状细胞癌患者。不同类型的细胞学标本，包括涂片、细胞离心涂片、细胞块和冲洗液中的吸出物，均可用于不同类型的HPV检测，如p16免疫组织化学、HPV原位杂交和HPV聚合酶链反应。目前对于细胞学标本中高危HPV检测尚无共识。建立标准化的细胞学标本HPV检测至关重要，且备受期待。
