Seemann Johanna, Eppard Elisabeth, Waldron Bradley P, Ross Tobias L, Roesch Frank
Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Department of Nuclear Medicine, Hannover Medical School, 30625 Hannover, Germany.
Appl Radiat Isot. 2015 Apr;98:54-9. doi: 10.1016/j.apradiso.2015.01.023. Epub 2015 Jan 22.
Interest in (68)Ga has led to a number of innovations for its provision suitable for clinical application. Several post-processing methods are available to reduce eluate volume and remove metal trace impurities. In this work three cation exchange resin based post-processing methods (acetone, ethanol and NaCl) have been compared, using three model precursors (DOTATOC, NO2AP(BP) and DATA(m)), in terms of labelling yield and reproducibility. The acetone and ethanol based methods provided greater reproducibility and yields that makes subsequent purification unnecessary.
对（68）镓的关注引发了一系列适用于临床应用的供应创新。有几种后处理方法可用于减少洗脱液体积并去除金属痕量杂质。在这项工作中，使用三种模型前体（DOTATOC、NO2AP(BP) 和 DATA(m)），就标记产率和重现性而言，比较了三种基于阳离子交换树脂的后处理方法（丙酮、乙醇和氯化钠）。基于丙酮和乙醇的方法具有更高的重现性和产率，无需后续纯化。
