Sanderink G J, Artur Y, Paille F, Siest G
Laboratoire du Centre de Médecine Préventive, UA CNRS no. 597, Vandoeuvre-les-Nancy, France.
Clin Chim Acta. 1989 Jan 13;179(1):23-31. doi: 10.1016/0009-8981(89)90019-3.
The potential clinical interest of a new isoform of alanine aminopeptidase (AAP) was examined using polyacrylamide gradient gel electrophoresis. This form, called F-AAP, is more proteolyzed than normal serum AAP. It appears to be associated with many liver diseases and is related to cytolysis, but also to elevated GGT levels. The F-AAP form was present in 52% of subjects treated with anticonvulsant drugs and in 64% of subjects consuming more than 44 g of alcohol per day. Analysis of F-AAP may be of interest in detecting effects of drugs and alcohol on the liver.
