饥荒与盛宴：理解体内肿瘤的代谢
Famine versus feast: understanding the metabolism of tumors in vivo.
作者信息
Mayers Jared R, Vander Heiden Matthew G
机构信息
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
出版信息
Trends Biochem Sci. 2015 Mar;40(3):130-40. doi: 10.1016/j.tibs.2015.01.004. Epub 2015 Jan 29.
To fuel unregulated proliferation, cancer cells alter metabolism to support macromolecule biosynthesis. Cell culture studies have revealed how different oncogenic mutations and nutrients impact metabolism. Glucose and glutamine are the primary fuels used in vitro; however, recent studies have suggested that utilization of other amino acids as well as lipids and protein can also be important to cancer cells. Early investigations of tumor metabolism are translating these findings to the biology of whole tumors and suggest that additional complexity exists beyond nutrient availability alone in vivo. Whole-body metabolism and tumor heterogeneity also influence the metabolism of tumor cells, and successful targeting of metabolism for cancer therapy will require an understanding of tumor metabolism in vivo.
为了促进不受调控的增殖，癌细胞会改变新陈代谢以支持大分子生物合成。细胞培养研究揭示了不同的致癌突变和营养物质如何影响新陈代谢。葡萄糖和谷氨酰胺是体外使用的主要燃料；然而，最近的研究表明，其他氨基酸以及脂质和蛋白质的利用对癌细胞也可能很重要。肿瘤代谢的早期研究正在将这些发现转化为整个肿瘤的生物学特性，并表明体内仅营养物质可用性之外还存在其他复杂性。全身新陈代谢和肿瘤异质性也会影响肿瘤细胞的代谢，而成功将代谢作为癌症治疗靶点将需要了解体内肿瘤代谢情况。
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