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The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat.

作者信息

Ho L T, Chern Y F, Lin M T

机构信息

Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan.

出版信息

Experientia. 1989 Feb 15;45(2):161-2. doi: 10.1007/BF01954859.

DOI:10.1007/BF01954859
PMID:2563980
Abstract

The level of somatostatin in the hypothalamus was higher in satiated rats than in hungry rats. Elevating hypothalamic somatostatin levels by administering somatostatin into the hypothalamus produced a decrease in food intake, whereas lowering hypothalamic somatostatin levels by administering cysteamine into the peritoneal cavity produced an increase in food intake in rats.

摘要

相似文献

1
The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat.
Experientia. 1989 Feb 15;45(2):161-2. doi: 10.1007/BF01954859.
2
Somatostatin: a hypothalamic transmitter for thermoregulation in rats.生长抑素：大鼠体温调节的一种下丘脑递质。
Pflugers Arch. 1989 Mar;413(5):528-32. doi: 10.1007/BF00594185.
3
Role of somatostatin in the regulation of vasopressin secretion.生长抑素在抗利尿激素分泌调节中的作用。
Brain Res. 1988 Jun 14;452(1-2):212-8. doi: 10.1016/0006-8993(88)90025-x.
4
Cysteamine-induced enhancement of growth hormone-releasing factor (GRF) immunoreactivity in arcuate neurons: morphological evidence for putative somatostatin/GRF interactions within hypothalamus.半胱胺诱导弓状核神经元中生长激素释放因子（GRF）免疫反应性增强：下丘脑内假定的生长抑素/GRF相互作用的形态学证据。
Endocrinology. 1990 Nov;127(5):2551-60. doi: 10.1210/endo-127-5-2551.
5
[Influence of electrical stimulation of "hunger center" of the lateral hypothalamus and food reinforcements on myoelectrical activity of the gastro-esophageal sphincter and stomach in rabbits under the conditions of hunger and satiation].[饥饿和饱腹状态下，电刺激家兔下丘脑外侧“饥饿中枢”及食物强化对胃食管括约肌和胃肌电活动的影响]
Eksp Klin Gastroenterol. 2013(9):43-51.
6
Relationship between feeding and satiation centers of the hypothalamus.下丘脑进食与饱腹感中枢之间的关系。
Science. 1960 Sep 23;132(3430):805-6. doi: 10.1126/science.132.3430.805.
7
Effects of cysteamine and pantethine on open-field behavior, hypothalamic catecholamine concentrations, and somatostatin-induced barrel rotation in rats.半胱胺和泛硫乙胺对大鼠旷场行为、下丘脑儿茶酚胺浓度及生长抑素诱导的躯体旋转的影响。
Pharmacol Biochem Behav. 1989 Mar;32(3):629-35. doi: 10.1016/0091-3057(89)90009-9.
8
Effects of cysteamine administration on the in vivo incorporation of [35S]cysteine into somatostatin-14, somatostatin-28, arginine vasopressin, and oxytocin in rat hypothalamus.给予半胱胺对大鼠下丘脑内[35S]半胱氨酸掺入生长抑素-14、生长抑素-28、精氨酸加压素和催产素的影响。
Endocrinology. 1986 Sep;119(3):1292-7. doi: 10.1210/endo-119-3-1292.
9
Hypothalamic involvement in the hyperglycemia and satiety actions of somatostatin in rats.
Neuroendocrinology. 1987 Jan;45(1):62-7. doi: 10.1159/000124704.
10
Evidence for selective release of somatostatin-14 and somatostatin-28(1-12) from rat hypothalamus.大鼠下丘脑选择性释放生长抑素-14和生长抑素-28(1-12)的证据。
J Neurosci. 1984 Feb;4(2):411-9. doi: 10.1523/JNEUROSCI.04-02-00411.1984.

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本文引用的文献

1
Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats.
Pharmacol Biochem Behav. 1982 Aug;17(2):249-53. doi: 10.1016/0091-3057(82)90078-8.
2
The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor.食欲的神经内分泌控制：内源性阿片肽、胆囊收缩素、促甲状腺激素释放激素、γ-氨基丁酸及地西泮受体的作用。
Life Sci. 1980 Aug 4;27(5):355-68. doi: 10.1016/0024-3205(80)90183-6.
3
Cholecystokinin acts through catecholaminergic mechanisms in the hypothalamus to influence ingestive behaviour in the rat.缩胆囊素通过下丘脑的儿茶酚胺能机制发挥作用，以影响大鼠的摄食行为。
Neuropharmacology. 1984 Nov;23(11):1351-6. doi: 10.1016/0028-3908(84)90059-5.
4
Effects of somatostatin on food intake in rats.生长抑素对大鼠食物摄取的影响。
Life Sci. 1984 Aug 13;35(7):741-6. doi: 10.1016/0024-3205(84)90342-4.
5
Cell-free synthesized precursor to somatostatin-28 from the rat hypothalamus.来自大鼠下丘脑的无细胞合成的生长抑素-28前体。
Brain Res. 1984 Jan 30;292(1):93-8. doi: 10.1016/0006-8993(84)90893-x.
6
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat.大鼠下丘脑室旁核中投射至延髓或脊髓的神经元的免疫组织化学鉴定。
J Comp Neurol. 1982 Mar 1;205(3):260-72. doi: 10.1002/cne.902050306.
7
Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.下丘脑和胰腺中生长抑素-28-(1-12)的存在。
Proc Natl Acad Sci U S A. 1982 Feb;79(3):917-21. doi: 10.1073/pnas.79.3.917.
8
Isolation and characterization of rat pancreatic somatostatin.大鼠胰腺生长抑素的分离与鉴定。
Endocrinology. 1980 Dec;107(6):2127-9. doi: 10.1210/endo-107-6-2127.
9
Cholecystokinin decreases food intake in rats.胆囊收缩素可减少大鼠的食物摄入量。
J Comp Physiol Psychol. 1973 Sep;84(3):488-95. doi: 10.1037/h0034870.
10
Hypothalamic involvement in the locomotor stimulant or satiety action of thyrotropin-releasing hormone and amphetamine.
Pharmacology. 1985;30(5):259-65. doi: 10.1159/000138076.