Strauchen J A
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029.
Hematol Oncol. 1989 Mar-Apr;7(2):149-53. doi: 10.1002/hon.2900070206.
The utility of immunohistochemical staining for leukocyte common antigen (LCA) in the differential diagnosis of Hodgkin's disease was studied in a series of 42 cases of Hodgkin's and non-Hodgkin's lymphoma and compared with Leu M-1, a proposed marker for Reed-Sternberg cells. LCA staining of neoplastic cells was absent in 23 of 24 cases of Hodgkin's disease but present in 16 of 18 cases of non-Hodgkin's lymphoma including eight of 10 cases with pleomorphic Reed-Sternberg-like cells. Leu M-1, in contrast was present in 14 of 24 cases of Hodgkin's disease, but also in five of 18 cases of non-Hodgkin's lymphoma including five of 10 cases with pleomorphic Reed-Sternberg-like cells. Immunohistochemical staining for LCA appears useful in the differential diagnosis of Hodgkin's disease and appears to be a better discriminant than Leu M-1.
对42例霍奇金病和非霍奇金淋巴瘤患者进行研究，探讨免疫组化染色检测白细胞共同抗原（LCA）在霍奇金病鉴别诊断中的应用价值，并与一种提议用于里德-斯腾伯格细胞的标志物Leu M-1进行比较。24例霍奇金病患者中有23例肿瘤细胞LCA染色阴性，而18例非霍奇金淋巴瘤患者中有16例肿瘤细胞LCA染色阳性，其中包括10例具有多形性里德-斯腾伯格样细胞的患者中的8例。相比之下，Leu M-1在24例霍奇金病患者中有14例呈阳性，但在18例非霍奇金淋巴瘤患者中也有5例呈阳性，其中包括10例具有多形性里德-斯腾伯格样细胞的患者中的5例。LCA免疫组化染色在霍奇金病的鉴别诊断中似乎有用，并且似乎比Leu M-1具有更好的鉴别能力。
