Knight Cardiovascular Institute, Oregon Health & Sciences University, Portland, OR.
Jewish General Hospital, Montreal, Quebec, Canada.
Trends Cardiovasc Med. 2015 Jul;25(5):445-51. doi: 10.1016/j.tcm.2014.12.006. Epub 2014 Dec 17.
Bicuspid aortic valve is a simple yet common condition with surprising clinical complexity. Patients are typically found to have enlargement of the ascending aorta, either root or midascending, independent of valve function. This enlargement is perceived to be a risk of aortic dissection, and therefore, prophylactic surgery is often recommended when the aorta reaches 50-55 mm in diameter. Despite the prevalence and potential health impact, there is to date no published data on the role of medical therapy. The emerging trend, however, is to address this question through clinical research. Early trials are underway designed to address the question of potential medical therapy. This article reviews current knowledge of the condition, its potential etiology, and ongoing work to assess the role of medical therapy.
二叶式主动脉瓣是一种简单而常见的疾病，但临床表现却出人意料地复杂。通常会发现患者的升主动脉扩张，无论是根部还是升主动脉中段，与瓣膜功能无关。这种扩张被认为是主动脉夹层的风险因素，因此，当主动脉直径达到 50-55 毫米时，通常会建议预防性手术。尽管这种情况很常见，且可能对健康有影响，但迄今为止，尚无关于药物治疗作用的发表数据。然而，目前的趋势是通过临床研究来解决这个问题。目前正在进行早期试验，旨在解决潜在药物治疗的问题。本文回顾了该疾病的现有知识、其潜在病因以及正在进行的评估药物治疗作用的工作。
