Abdulkareem Nada, Smelt Jeremy, Jahangiri Marjan
Department of Cardiothoracic Surgery, St. George's Hospital, University of London, London, UK.
Interact Cardiovasc Thorac Surg. 2013 Sep;17(3):554-9. doi: 10.1093/icvts/ivt196. Epub 2013 May 31.
The association between ascending aortic aneurysm (AA) and bicuspid aortic valve (BAV) has been well established. Different genetic, haemodynamic and cardiovascular risk factors have been implicated in the development and progression of AA. However, to date, definite conclusions cannot be drawn regarding the exact molecular, cellular and haemodynamic mechanisms causing BAV-associated aortopathy. For this study, we performed a thorough electronic systematic review of the literature using MEDLINE (1960-2012) and EMBASE databases. MeSH terms included: 'bicuspid aortic valve and ascending aorta', 'bicommissural aortic valve and aneurysm', 'bicuspid aortopathy', 'bicuspid aortic valve pathophysiology', 'bicuspid aortic valve and genetics' and 'bicuspid aortic valve and treatment'. We aim in this review to discuss the mechanisms, pathophysiology, genetics and modern drug therapy in the context of BAV-associated aortopathy.
升主动脉瘤（AA）与二叶式主动脉瓣（BAV）之间的关联已得到充分证实。不同的遗传、血流动力学和心血管危险因素与AA的发生和发展有关。然而，迄今为止，关于导致BAV相关主动脉病变的确切分子、细胞和血流动力学机制，仍无法得出明确结论。在本研究中，我们使用MEDLINE（1960 - 2012）和EMBASE数据库对文献进行了全面的电子系统综述。医学主题词包括：“二叶式主动脉瓣与升主动脉”、“双连合主动脉瓣与动脉瘤”、“二叶式主动脉病变”、“二叶式主动脉瓣病理生理学”、“二叶式主动脉瓣与遗传学”以及“二叶式主动脉瓣与治疗”。在本综述中，我们旨在探讨BAV相关主动脉病变背景下的机制、病理生理学、遗传学和现代药物治疗。
