Omari-Asor Lorraine, Stewart Robert, Artero Sylvaine, Ritchie Karen
King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, SE5 8AF, UK.
Inserm, U888, Montpellier, F-34093, France.
Int J Geriatr Psychiatry. 2015 Oct;30(10):1017-22. doi: 10.1002/gps.4255. Epub 2015 Jan 30.
Associations between environmental risk factors and depression have been reported to be stronger in people with the S allele of the S/L polymorphism in the serotonin transporter gene-linked promoter region (5-HTTLPR); however, most studies have focused on adverse life events as a general exposure, and interactions with physical disorders have been less investigated. We therefore investigated associations of asthma and diabetes with depression in an older community population and compared these by 5-HTTLPR genotype.
A sample of 1617 people aged 65 years and over, from Montpellier, France, were examined for depression, using the Center for Epidemiologic Studies Depression Scale and Mini International Neuropsychiatric Interview assessments, and a standardised interview was conducted to establish physical health status. Blood samples were also taken for 5-HTTLPR genotype.
Depression was significantly associated with asthma and diabetes but not with 5-HTTLPR genotype. After adjustment for age, sex, education and co-residency, the association between asthma and depression did increase in strength and significance across genotype groups (odds ratios in LL, SL and SS genotypes: 1.59 (0.66-3.82), 1.88 (1.05-3.36) and 3.00 (1.26-7.13), respectively) although the interaction term fell below statistical significance (p = 0.29). No modification was observed for diabetes as an exposure.
The findings provided some support for effect modification by 5-HTTLPR genotype for asthma but for not diabetes as risk factors for depression.
据报道，在血清素转运体基因连锁启动子区域（5-HTTLPR）的S/L多态性的S等位基因携带者中，环境风险因素与抑郁症之间的关联更强；然而，大多数研究集中在将不良生活事件作为一种普遍暴露因素，而对其与身体疾病的相互作用研究较少。因此，我们调查了老年社区人群中哮喘和糖尿病与抑郁症的关联，并按5-HTTLPR基因型进行比较。
对来自法国蒙彼利埃的1617名65岁及以上的老年人进行抽样，使用流行病学研究中心抑郁量表和迷你国际神经精神病学访谈评估法检查抑郁症情况，并通过标准化访谈确定身体健康状况。还采集血样检测5-HTTLPR基因型。
抑郁症与哮喘和糖尿病显著相关，但与5-HTTLPR基因型无关。在对年龄、性别、教育程度和同住情况进行调整后，哮喘与抑郁症之间的关联在各基因型组中强度和显著性确实有所增加（LL、SL和SS基因型的比值比分别为：1.59（0.66 - 3.82）、1.88（1.05 - 3.36）和3.00（1.26 - 7.13）），尽管交互项低于统计学显著性（p = 0.29）。未观察到糖尿病作为暴露因素时有任何改变。
研究结果为5-HTTLPR基因型对哮喘作为抑郁症风险因素存在效应修饰作用提供了一些支持，但对糖尿病则未提供支持。
