INSERM U1061, Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, 34093 Montpellier cedex 5, France.
Br J Psychiatry. 2011 Jul;199(1):43-8. doi: 10.1192/bjp.bp.110.087924. Epub 2011 May 18.
In 1962 approximately 1.5 million French people living in Algeria were repatriated to France in very poor and often life-threatening conditions. These people constitute a cohort for the study of the long-term impact of gene-environment interaction on depression.
To examine the interaction between a highly stressful life event and subsequent depression, and its modulation by a length polymorphism of the serotonin transporter gene (5-HTTLPR).
A community sample of people aged 65 years and over residing in the Montpellier region of the south of France was randomly recruited from electoral rolls. Genotyping was performed on 248 repatriated persons and 632 controls. Current and lifetime major and minor depressive disorders were assessed according to DSM-IV criteria.
A significant relationship was observed between exposure to repatriation and subsequent depression (P<0.002), but there was no significant effect of gene alone (P = 0.62). After controlling for age, gender, education, disability, recent life events and cognitive function, the gene-environment interaction (repatriation × 5-HTTLPR) was globally significant (P<0.002; OR = 3.21, 95% CI 2.48-5.12). Individuals carrying the two short (s) alleles of 5-HTTLPR were observed to be at higher risk (P<0.005; OR = 2.34, 95% CI 1.24-4.32), particularly when repatriation occurred before age 35 years (P<0.002; OR = 2.91, 95% CI 1.44-5.88), but this did not reach significance in those who were older at the time of the event (P = 0.067).
The association between depression and war repatriation was significantly modulated by 5-HTTLPR genotype but this appeared to occur only in people who were younger at the time of exposure.
1962 年，约 150 万生活在阿尔及利亚的法国人在非常恶劣和经常危及生命的条件下被遣返回法国。这些人构成了研究基因-环境相互作用对抑郁症长期影响的队列。
研究高度应激性生活事件与随后抑郁症之间的相互作用，及其与 5-羟色胺转运体基因（5-HTTLPR）长度多态性的调制作用。
从法国南部蒙彼利埃地区的选民名单中随机招募了年龄在 65 岁及以上的社区样本。对 248 名被遣返者和 632 名对照者进行了基因分型。根据 DSM-IV 标准评估当前和终生的主要和次要抑郁障碍。
暴露于遣返与随后的抑郁症之间存在显著的关系（P<0.002），但基因本身的影响不显著（P=0.62）。在控制年龄、性别、教育、残疾、近期生活事件和认知功能后，基因-环境相互作用（遣返×5-HTTLPR）总体上具有显著性（P<0.002；OR=3.21，95%CI 2.48-5.12）。携带 5-HTTLPR 两个短（s）等位基因的个体被观察到处于更高的风险（P<0.005；OR=2.34，95%CI 1.24-4.32），特别是在遣返发生在 35 岁之前（P<0.002；OR=2.91，95%CI 1.44-5.88），但在遣返时年龄较大的个体中这一结果没有达到显著性（P=0.067）。
抑郁症与战争遣返之间的关联受到 5-HTTLPR 基因型的显著调节，但这种调节似乎仅发生在暴露时年龄较小的人群中。
