Mohan P F, Cleary M P
Hormel Institute, University of Minnesota, Austin 55912.
J Nutr. 1989 Mar;119(3):496-501. doi: 10.1093/jn/119.3.496.
The effects of either dehydroepiandrosterone (DHEA) or clofibric acid (CFA) treatment on obese female Zucker rats were compared. After 5 wk of treatment, food intake, body weight gain and food efficiency ratio of DHEA-treated rats were 85, 64 and 75%, respectively, of those of CFA-treated and control rats. Liver weights of DHEA- and CFA-treated rats were higher than those of control rats. Non-fasting serum glucose levels were similar in all groups, but serum insulin level of DHEA-treated rats was 59% of that in CFA-treated and control rats. Results of glucose tolerance tests were not different among the groups. Mitochondrial state 3 and 4 rates expressed per g liver or per liver with either glutamate-malate or succinate as substrate were higher in DHEA-treated rats than in CFA-treated or control rats. Mitochondrial long-chain fatty acyl-CoA hydrolase activity was 8.5 and 4 times higher in DHEA- and CFA-treated rats, respectively, than in control rats. These results suggest that although DHEA and CFA affect some hepatic biochemical parameters similarly, they are distinct in their effects on body weight, serum insulin and mitochondrial respiration in obese Zucker rats.
比较了脱氢表雄酮（DHEA）或氯贝酸（CFA）治疗对肥胖雌性 Zucker 大鼠的影响。治疗 5 周后，DHEA 治疗组大鼠的食物摄入量、体重增加和食物效率比分别为 CFA 治疗组和对照组大鼠的 85%、64%和 75%。DHEA 治疗组和 CFA 治疗组大鼠的肝脏重量高于对照组大鼠。所有组的非空腹血清葡萄糖水平相似，但 DHEA 治疗组大鼠的血清胰岛素水平是 CFA 治疗组和对照组大鼠的 59%。葡萄糖耐量试验结果在各组之间没有差异。以谷氨酸-苹果酸或琥珀酸为底物时，DHEA 治疗组大鼠每克肝脏或整个肝脏的线粒体状态 3 和状态 4 呼吸速率高于 CFA 治疗组或对照组大鼠。DHEA 治疗组和 CFA 治疗组大鼠的线粒体长链脂肪酰辅酶 A 水解酶活性分别比对照组大鼠高 8.5 倍和 4 倍。这些结果表明，虽然 DHEA 和 CFA 对某些肝脏生化参数的影响相似，但它们对肥胖 Zucker 大鼠的体重、血清胰岛素和线粒体呼吸的影响是不同的。
