Cleary M P, Zisk J F
Int J Obes. 1986;10(3):193-204.
Dehydroepiandrosterone has previously been shown to prevent weight gain in growing lean and obese mice and rats. In the present study, lean and obese female Zucker rats were treated with either 0.6 or 1.0 percent DHEA in the diet from 8 until 14 months of age. In lean rats, 0.6 percent DHEA prevented weight gain and 1.0 percent DHEA resulted in significant weight loss compared to initial body weight. Control lean rats had a significant weight gain. Both 0.6 and 1.0 percent DHEA obese rats lost weight over the experimental period while control obese rats gained weight. Food intake of DHEA-treated obese rats was lowered compared to control obese rats but was similar to that of all lean groups. DHEA lowered serum insulin levels in both lean and obese rats relative to control groups. Both 0.6 and 1.0 percent DHEA lean rats had elevated hepatic G6PD activity compared to control lean rats. DHEA obese rats had lowered G6PD activity compared to the control obese rats. Hepatic malic enzyme was elevated by DHEA treatment in both lean and obese Zucker rats. Adipose tissue weights were lowered substantially in DHEA treated lean and obese rats versus their control groups. These data indicate that DHEA treatment in adult rats has an anti-obesity effect.
脱氢表雄酮此前已被证明可防止生长中的瘦型和肥胖型小鼠及大鼠体重增加。在本研究中，从8个月龄至14个月龄，给瘦型和肥胖型雌性 Zucker 大鼠喂食含0.6%或1.0%脱氢表雄酮的饲料。在瘦型大鼠中，与初始体重相比，0.6%的脱氢表雄酮可防止体重增加，而1.0%的脱氢表雄酮则导致显著体重减轻。对照瘦型大鼠体重显著增加。在实验期间，0.6%和1.0%的脱氢表雄酮处理的肥胖型大鼠均体重减轻，而对照肥胖型大鼠体重增加。与对照肥胖型大鼠相比，脱氢表雄酮处理的肥胖型大鼠食物摄入量降低，但与所有瘦型组相似。与对照组相比，脱氢表雄酮降低了瘦型和肥胖型大鼠的血清胰岛素水平。与对照瘦型大鼠相比，0.6%和1.0%的脱氢表雄酮处理的瘦型大鼠肝葡萄糖-6-磷酸脱氢酶（G6PD）活性升高。与对照肥胖型大鼠相比，脱氢表雄酮处理的肥胖型大鼠G6PD活性降低。脱氢表雄酮处理使瘦型和肥胖型 Zucker 大鼠的肝苹果酸酶活性升高。与对照组相比，脱氢表雄酮处理的瘦型和肥胖型大鼠脂肪组织重量大幅降低。这些数据表明，成年大鼠接受脱氢表雄酮治疗具有抗肥胖作用。
