全反式维甲酸在Foxp3+调节性T细胞生物学中的作用。
The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells.
作者信息
Liu Zhong-Min, Wang Kun-Peng, Ma Jilin, Guo Zheng Song
机构信息
Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China.
Division of Rheumatology, Penn State Hershey College of Medicine, Hershey, PA, USA.
出版信息
Cell Mol Immunol. 2015 Sep;12(5):553-7. doi: 10.1038/cmi.2014.133. Epub 2015 Feb 2.
Abstract
Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. Foxp3(+) Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
摘要
调节性T（Treg）细胞对于免疫系统的稳态维持和自身免疫性疾病的预防至关重要。Foxp3在Treg细胞中特异性表达，并在其分化和功能中发挥关键作用。Foxp3(+) Treg细胞由天然存在的、源自胸腺的Treg（nTreg）和外周诱导的Treg（iTreg）细胞组成，它们可能具有不同的功能特征或协同作用。全反式维甲酸（atRA）是一种维生素A代谢产物，可调节广泛的生物学过程，包括细胞分化和增殖。最近的研究表明，atRA还调节辅助性T（Th）细胞和Treg细胞的分化。此外，atRA在炎症条件下还能维持nTreg的稳定性。在本综述中，我们总结了我们对atRA在Treg生物学中的作用和机制的理解所取得的重大进展。
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