College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
College of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450052, China.
Biosensors (Basel). 2022 Sep 30;12(10):809. doi: 10.3390/bios12100809.
Copper ions, as the active centers of natural enzymes, play an important role in many physiological processes. Copper ion-based catalysts which mimic the activity of enzymes have been widely used in the field of industrial catalysis and sensing devices. As an important class of small biological molecules, peptides have the advantages of easy synthesis, excellent biocompatibility, low toxicity, and good water solubility. The peptide-copper complexes exhibit the characteristics of low molecular weight, high tenability, and unique catalytic and photophysical properties. Biosensors with peptide-copper complexes as the signal probes have promising application prospects in environmental monitoring and biomedical analysis and diagnosis. In this review, we discussed the design and application of fluorescent, colorimetric and electrochemical biosensors based on the peptide-copper coordination interaction.
铜离子作为天然酶的活性中心，在许多生理过程中发挥着重要作用。模拟酶活性的基于铜离子的催化剂已被广泛应用于工业催化和传感设备领域。作为一类重要的小分子生物分子，肽具有合成容易、生物相容性好、毒性低、水溶性好等优点。肽-铜配合物具有分子量低、可修饰性高、独特的催化和光物理性质等特点。以肽-铜配合物作为信号探针的生物传感器在环境监测以及生物医学分析和诊断方面具有广阔的应用前景。本综述讨论了基于肽-铜配位相互作用的荧光、比色和电化学生物传感器的设计和应用。
