Duy Mac Khuong, Su Judith
Department of Biomedical Engineering, The University of Arizona, Tucson, AZ USA.
Wyant College of Optical Sciences, The University of Arizona, Tucson, AZ USA.
NPJ Biosens. 2025;2(1):20. doi: 10.1038/s44328-025-00040-3. Epub 2025 May 2.
Neurodegenerative diseases involve the progressive loss of neurons in the brain and nervous system, leading to functional decline. Early detection is critical for improving outcomes and advancing therapies. Optical biosensors, some of which offer rapid, label-free, and ultra-sensitive detection, have been applied to early diagnosis and drug screening. This review examines the principles and performance of different optical biosensors used for diagnosing neurodegenerative diseases and discusses potential future advancements.
神经退行性疾病涉及大脑和神经系统中神经元的逐渐丧失，导致功能衰退。早期检测对于改善治疗结果和推进治疗方法至关重要。光学生物传感器，其中一些具有快速、无标记和超灵敏检测的特点，已被应用于早期诊断和药物筛选。本文综述了用于诊断神经退行性疾病的不同光学生物传感器的原理和性能，并讨论了未来潜在的进展。
