Rh2(II)-催化的酯迁移反应，从三取代的苯乙烯基叠氮化物中得到 3H-吲哚。
Rh2(II)-catalyzed ester migration to afford 3H-indoles from trisubstituted styryl azides.
机构信息
Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
出版信息
Org Lett. 2015 Feb 20;17(4):802-5. doi: 10.1021/ol503541z. Epub 2015 Feb 2.
PMID:25642741
Abstract
Rh2(II)-complexes trigger the formation of 3H-indoles from ortho-alkenyl substituted aryl azides. This reaction occurs through a 4π-electron-5-atom electrocyclization of the rhodium N-aryl nitrene followed by a [1,2]-migration to afford only 3H-indoles. The selectivity of the migration is dependent on the identity of the β-styryl substituent.
摘要
Rh2(II)-配合物引发邻烯基取代芳基叠氮化物生成 3H-吲哚。该反应通过铑 N-芳基氮宾的 4π-电子-5-原子电环化发生，随后进行[1,2]-迁移，仅得到 3H-吲哚。迁移的选择性取决于β-苯乙烯取代基的身份。
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