兔离体隐静脉远段功能性节后α2肾上腺素能受体的表达——血管紧张素II的许可作用？
Expression of functional postjunctional alpha 2-adrenoceptors in rabbit isolated distal saphenous artery--a permissive role for angiotensin II?
作者信息
Dunn W R, McGrath J C, Wilson V G
机构信息
Autonomic Physiology Unit, University of Glasgow.
出版信息
Br J Pharmacol. 1989 Feb;96(2):259-61. doi: 10.1111/j.1476-5381.1989.tb11810.x.
Abstract
In the rabbit isolated distal saphenous artery, the population of postjunctional adrenoceptors is of the alpha 1 variety under normal in vitro experimental conditions, based on the potency order of selective agonists and on the effects of the antagonists prazosin and rauwolscine against responses to UK-14304. Angiotensin II (A II, 0.05 microM) however, without affecting resting baseline tension, markedly enhanced responses to UK-14304, particularly at low concentrations. This previously unseen component of the response to UK-14304 was resistant to prazosin (0.1 microM) but susceptible to rauwolscine (1 microM). A II would therefore appear to have a permissive role for the expression of a quiescent population of postjunctional alpha 2-adrenoceptors in the rabbit distal saphenous artery.
摘要
在兔离体隐静脉远段动脉中，根据选择性激动剂的效价顺序以及拮抗剂哌唑嗪和萝芙辛对UK - 14304反应的影响，在正常体外实验条件下，节后肾上腺素能受体群体属于α1型。然而，血管紧张素II（A II，0.05微摩尔）在不影响静息基线张力的情况下，显著增强了对UK - 14304的反应，尤其是在低浓度时。这种对UK - 14304反应中以前未见过的成分对哌唑嗪（0.1微摩尔）有抗性，但对萝芙辛（1微摩尔）敏感。因此，A II似乎对兔隐静脉远段动脉中静止的节后α2 - 肾上腺素能受体群体的表达具有允许作用。
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