McCarthy Kate
University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.
Semin Respir Crit Care Med. 2015 Feb;36(1):44-55. doi: 10.1055/s-0034-1396907. Epub 2015 Feb 2.
Pseudomonas aeruginosa is a formidable pathogen in the infection arena. It is able to easily adapt to the environment which it inhabits and can also colonize and invade the human host to cause serious infections. In 2011, it was responsible for 7.1% of all health care-associated infection in the United States. The morbidity and mortality of both blood stream infections and ventilator-associated pneumonia are significant. On a global scale, we have seen the development of not only multidrug resistance but also extensive and pan drug resistance in this organism. This is often associated with limited clonal types of which we now have epidemiological evidence of spread. With this has come reduced antibiotic treatment options. Consideration of antibiotic infusions, combination therapy, and inhalational therapy has occurred in an attempt to gain the upper ground. Gram-negative resistance has appropriately been described as a global emergency.
铜绿假单胞菌是感染领域中一种可怕的病原体。它能够轻松适应其所处的环境，还能在人类宿主中定植并侵入，从而引发严重感染。2011年，在美国所有医疗保健相关感染中，它占7.1%。血流感染和呼吸机相关性肺炎的发病率和死亡率都很高。在全球范围内，我们不仅看到了这种微生物多重耐药性的出现，还看到了广泛耐药和泛耐药的情况。这通常与有限的克隆类型有关，目前我们已有这些克隆类型传播的流行病学证据。随之而来的是抗生素治疗选择的减少。人们已经考虑采用抗生素输注、联合治疗和吸入治疗，试图占据上风。革兰氏阴性菌耐药性已被恰当地描述为一场全球紧急情况。
