Hammerman Peter S, Hayes D Neil, Grandis Jennifer R
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
Department of Hematology/Oncology, University of North Carolina Lineberger Cancer Center, Chapel Hill, North Carolina.
Cancer Discov. 2015 Mar;5(3):239-44. doi: 10.1158/2159-8290.CD-14-1205. Epub 2015 Feb 2.
Large and comprehensive genomic surveys of head and neck squamous cell carcinomas (HNSCC) are now greatly increasing our understanding of the diversity of this disease and the key genomic changes that drive these tumors. The results from these studies are beginning to inform the introduction of novel therapies for patients with HNSCCs. Here, we review some of the key findings from recent genomic studies of head and neck cancers, including the most comprehensive study to date from The Cancer Genome Atlas Network.
对头颈部鳞状细胞癌（HNSCC）进行的大规模综合基因组调查，正极大地增进我们对这种疾病多样性以及驱动这些肿瘤发生的关键基因组变化的理解。这些研究结果开始为HNSCC患者引入新疗法提供依据。在此，我们回顾近期头颈癌基因组研究的一些关键发现，包括癌症基因组图谱网络（The Cancer Genome Atlas Network）迄今为止最全面的研究。
