Puram Sidharth V, Rocco James W
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114, USA; Department of Otology and Laryngology, Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA.
Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, James Cancer Hospital, Solove Research Institute, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA.
Hematol Oncol Clin North Am. 2015 Dec;29(6):971-92. doi: 10.1016/j.hoc.2015.07.003. Epub 2015 Oct 17.
In spite of a rapidly expanding understanding of head and neck tumor biology and optimization of radiation, chemotherapy, and surgical treatment modalities, head and neck squamous cell carcinoma (HNSCC) remains a major cause of cancer-related morbidity and mortality. Although our biologic understanding of these tumors had largely been limited to pathways driving proliferation, survival, and differentiation, the identification of HPV as a major driver of HNSCC and genomic sequencing analyses has dramatically influenced our understanding of tumor biology and approach to therapy. Here, we summarize molecular aspects of HNSCC biology and identify promising areas for potential diagnostic and therapeutic agents.
尽管对头颈部肿瘤生物学的认识迅速扩展，并且放疗、化疗和手术治疗方式得到了优化，但头颈部鳞状细胞癌（HNSCC）仍然是癌症相关发病和死亡的主要原因。虽然我们对这些肿瘤的生物学认识在很大程度上仅限于驱动增殖、存活和分化的途径，但人乳头瘤病毒（HPV）作为HNSCC的主要驱动因素的鉴定以及基因组测序分析极大地影响了我们对肿瘤生物学和治疗方法的理解。在此，我们总结了HNSCC生物学的分子方面，并确定了潜在诊断和治疗药物的有前景领域。
