Poliseno Laura, Pandolfi Pier Paolo
Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori, Pisa, Italy; Institute of Clinical Physiology, CNR, Pisa, Italy.
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Methods. 2015 May;77-78:41-50. doi: 10.1016/j.ymeth.2015.01.013. Epub 2015 Jan 30.
In multiple human cancer types, a close link exists between the expression levels of Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN) and its oncosuppressive activities. Therefore, an in depth understanding of the molecular mechanisms by which PTEN expression is modulated is crucial in order to achieve a comprehensive knowledge of its biological roles. In recent years, the competition between PTEN mRNA and other RNAs for shared microRNA molecules has emerged as one such mechanism and has brought into focus the coding-independent activities of PTEN and other mRNAs. In this review article, we examine the competing endogenous RNA (ceRNA) partners of PTEN that have been identified so far. We also discuss how PTEN-centered ceRNA networks can contribute to a deeper understanding of PTEN function and tumorigenesis.
在多种人类癌症类型中，10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）的表达水平与其抑癌活性之间存在密切联系。因此，深入了解PTEN表达调控的分子机制对于全面认识其生物学作用至关重要。近年来，PTEN mRNA与其他RNA竞争共享微小RNA分子的机制逐渐浮出水面，这也使PTEN和其他mRNA的非编码依赖性活性成为焦点。在这篇综述文章中，我们研究了目前已确定的PTEN的竞争性内源RNA（ceRNA）伙伴。我们还讨论了以PTEN为中心的ceRNA网络如何有助于更深入地理解PTEN功能和肿瘤发生。
