Ferzoco Raina M, Ruddy Kathryn J
Department of Oncology, Mayo Clinic, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA,
Curr Oncol Rep. 2015 Feb;17(2):1. doi: 10.1007/s11912-014-0425-x.
Breast cancer is the most commonly diagnosed malignancy in young women in the USA. Although breast cancer mortality has decreased overall, survival rates in young women remain lower than those in older women. Young women with breast cancer comprise a special population due to the aggressive biology of their tumors as well as their unique psychosocial concerns. Although general treatment principles are similar regardless of age, recent developments from research focused on younger women have provided new insights to guide treatment of this special population. This article will focus on these new developments in areas including endocrine therapy and fertility preservation as well as the unique treatment-related sequelae and psychosocial concerns among young women with breast cancer face.
乳腺癌是美国年轻女性中最常被诊断出的恶性肿瘤。尽管乳腺癌总体死亡率有所下降,但年轻女性的生存率仍低于老年女性。患有乳腺癌的年轻女性构成了一个特殊群体,这是由于她们肿瘤的侵袭性生物学特性以及独特的心理社会问题。尽管无论年龄大小,一般治疗原则相似,但针对年轻女性的研究新进展为指导这一特殊群体的治疗提供了新的见解。本文将聚焦于内分泌治疗和生育力保存等领域的这些新进展,以及乳腺癌年轻女性面临的与治疗相关的独特后遗症和心理社会问题。