用于穿越血脑屏障和高效核酸递送的高渗聚木糖醇
Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery.
作者信息
Garg P, Pandey S, Seonwoo Hoon, Yeom Seungmin, Choung Yun-Hoon, Cho Chong-Su, Choung Pill-Hoon, Hoon Chung Jong
机构信息
Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-921, Republic of Korea.
出版信息
Chem Commun (Camb). 2015 Feb 28;51(17):3645-8. doi: 10.1039/c4cc09871d.
PMID:25645149
Abstract
Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.
摘要
在此，我们介绍一种基于聚木糖醇的高渗聚合物，它不仅可通过动脉内输注渗透性多元醇透过血脑屏障，还可通过调节小窝介导的内吞作用触发细胞摄取。
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