Gosavi Pallavi M, Moroz Yurii S, Korendovych Ivan V
Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA.
Chem Commun (Camb). 2015 Mar 28;51(25):5347-50. doi: 10.1039/c4cc08720h.
β-(1-Azulenyl)-L-alanine (AzAla) can be incorporated into the influenza A virus M2 proton channel. AzAla's sensitivity to the protonation state of the nearby histidines and the lack of environmental fluorescence dependence allow for direct and straightforward determination of histidine pKa values in ion channels.
β-(1-薁基)-L-丙氨酸（AzAla）可掺入甲型流感病毒M2质子通道。AzAla对附近组氨酸质子化状态的敏感性以及对环境荧光依赖性的缺乏，使得能够直接且简便地测定离子通道中组氨酸的pKa值。
