Edwards D S, Clasper J C, Patel H D L
Centre for Blast Injury Studies, Imperial College, South Kensington, London, UK Royal Centre for Defence Medicine, Surrey, UK.
Royal Centre for Defence Medicine, Surrey, UK Ministry of Defence Hospital Unit, Frimley Park Hospital, Surrey, UK.
J R Army Med Corps. 2015 Dec;161(4):345-7. doi: 10.1136/jramc-2014-000370. Epub 2015 Feb 2.
Heterotopic ossification (HO) is the formation of bone at extraskeletal sites. Over 60% of amputees injured by improvised explosive devices in the recent conflict in Afghanistan have developed HO, resulting in functional impairment. It is hypothesised that a key aetiological factor is the blast wave; however, other environmental and medical risk factors, which the casualties have been exposed to, have also been postulated. The suicide terrorist bombings in London in 2005 resulted in many blast-related casualties, many of whom were managed by the Royal London Hospital. This cohort of severely injured patients whose injuries also included trauma-related amputations shared some, but not all, of the risk factors identified in the military population. We reviewed these patients, in particular to assess the presence or absence of military-established risk factors for the formation of HO in these casualties.
异位骨化（HO）是指在骨骼外部位形成骨组织。在近期阿富汗冲突中，超过60%因简易爆炸装置受伤的截肢者发生了异位骨化，导致功能障碍。据推测，一个关键的病因因素是冲击波；然而，也有人提出，伤亡人员所接触到的其他环境和医疗风险因素也与此有关。2005年伦敦发生的自杀式恐怖爆炸事件造成了许多与爆炸相关的伤亡人员，其中许多人由皇家伦敦医院进行治疗。这群重伤患者的伤势还包括与创伤相关的截肢，他们具有一些（但并非全部）在军人中确定的危险因素。我们对这些患者进行了回顾，特别是为了评估这些伤亡人员中是否存在已确定的与异位骨化形成相关的军人危险因素。
