肾移植中意义未明的随访单克隆丙种球蛋白病
Follow-up monoclonal gammopathy of undetermined significance in kidney transplant.
作者信息
Cuéllar-García C, Sevillano Ruiz-Mateos C, Mazuecos Blanca M A, Narvaez Mejia C, Fernandez Valle M C, Martin Reina V, Gonzalez Bernal M, Yera Cobo M, Rodriguez Lopez R, de Cos Hohr C, Garrastazul M P, Marchante I, Paz Coll A, Capote Huelva F J
机构信息
Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
Hematology Service, Hospital Universitario Puerta del Mar, Cadiz, Spain.
出版信息
Transplant Proc. 2015 Jan-Feb;47(1):78-80. doi: 10.1016/j.transproceed.2014.11.021.
OBJECTIVE
The aim of this work was to review the incidence of monoclonal gammopathy of undetermined significance (MGUS) and complications in kidney transplant (KT) patients at the Puerta del Mar Hospital in Cádiz, Spain. This diagnosis was not considered to be a contraindication for transplantation.
METHODS
To estimate the incidence of MGUS in KT patients we used the database of our hospital, which included 1,016 patients who received a KT from 1992 to 2012 with a median follow-up of 30 months. The incidence of MGUS in non-transplant patients was estimated from the literature.
RESULTS
Out of 1,016 KT patients, 16 developed MGUS; 10 (72.5%) were >50 years old. Two patients developed post-transplantation lymphoproliferative disorders. No cases of progression to multiple myeloma or amyloidosis were seen during immune suppression therapy or after.
CONCLUSIONS
MGUS was >100 times more frequent in KT recipients than in the general population (P < .05). But in contrast to MGUS in general population, progression to plasma cell dyscrasia in these patients was absent and its incidence is unknown in KT patients.
目的
本研究旨在回顾西班牙加的斯市马尔港医院肾移植（KT）患者意义未明的单克隆丙种球蛋白病（MGUS）的发病率及并发症情况。该诊断不被视为移植的禁忌证。
方法
为估算KT患者中MGUS的发病率，我们使用了我院的数据库，其中包括1992年至2012年期间接受KT的1016例患者，中位随访时间为30个月。非移植患者中MGUS的发病率是根据文献估算的。
结果
在1016例KT患者中，16例发生了MGUS；10例（72.5%）年龄>50岁。2例患者发生了移植后淋巴细胞增生性疾病。在免疫抑制治疗期间或之后，未观察到进展为多发性骨髓瘤或淀粉样变性的病例。
结论
KT受者中MGUS的发生率比普通人群高100倍以上（P < .05）。但与普通人群中的MGUS不同，这些患者未出现进展为浆细胞发育异常的情况，且KT患者中其发病率未知。
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